購(gòu)物車(chē) 
-
Tingenin B
- names：
(6bR,8aR,9S,11R,12aS,12bS,14aS)-3,9-dihydroxy-4,6b,8a,11,12b,14a-hexamethyl-7,8,8a,11,12,12a,12b,13,14,14a-decahydropicene-2,10(6bH,9H)-dione
- CAS號(hào)：
50656-68-3
MDL Number： - MF(分子式)： C28H36O4 MW(分子量)： 436.59
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規(guī)格 | 純度 | 價(jià)格 (￥) | 現(xiàn)價(jià)(￥) | 特價(jià)(￥) | 庫(kù)存描述 | 數(shù)量 | 總計(jì) (￥) |
|---|
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| 中文別名 | (6bR,8aR,9S,11R,12aS,12bS,14aS)-3,9-dihydroxy-4,6b,8a,11,12b,14a-hexamethyl-7,8,8a,11,12,12a,12b,13,14,14a-decahydropicene-2,10(6bH,9H)-dione |
| 英文別名 | Tingenin B; 22-Hydroxytingenone; |
| CAS號(hào) | 50656-68-3 |
| Inchi | InChI=1S/C28H36O4/c1-15-13-21-26(4,24(32)22(15)30)10-12-27(5)20-8-7-17-16(2)23(31)19(29)14-18(17)25(20,3)9-11-28(21,27)6/h7-8,14-15,21,24,31-32H,9-13H2,1-6H3/t15-,21-,24-,25-,26-,27+,28+/m1/s1 |
| InchiKey | QIRUFAFQGKOTKA-LSWNLOKNSA-N |
| 分子式 Formula | C28H36O4 |
| 分子量 Molecular Weight | 436.59 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲(chǔ)藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產(chǎn)品說(shuō)明 | Tingenin B(CAS:50656-68-3):僅限應(yīng)用于工業(yè)或者科學(xué)研究過(guò)程中非醫(yī)療目的，不應(yīng)用于人類(lèi)或動(dòng)物的臨床診斷以及治過(guò)程療，該產(chǎn)品非藥用，非食用。 |
| Introduction | Tingenin B, the plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro. This compounds target cancer stem cells (CSCs), Tingenin b was cytotoxic against MCF-7s (IC50 value for 48 h was found to be 2.38 μM) by inducing apoptosis. It was evident by Annexin V staining positivity, decreased mitochondrial membrane potential and Bcl-2 dephosphorylation with a concomitant increase in Bax protein expression. In addition, endoplasmic reticulum stress was also found to be involved in tingenin b-induced cell death. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Cevatemre B, Botta B, Mori M, Berardozzi S, Ingallina C, Ulukaya E. The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro. Chem Biol Interact. 2016 Dec 25;260:248-255. doi: 10.1016/j.cbi.2016.10.00[1]Epub 2016 Oct 5. PubMed PMID: 27720947. |
| [2]Bavovada R, Blaskó G, Shieh HL, Pezzuto JM, Cordell GA. Spectral assignment and cytotoxicity of 22-hydroxytingenone from Glyptopetalum sclerocarpum. Planta Med. 1990 Aug;56(4):380-2. PubMed PMID: 2236293. |
| [3] Maregesi SM, Hermans N, Dhooghe L, Cimanga K, Ferreira D, Pannecouque C, Vanden Berghe DA, Cos P, Maes L, Vlietinck AJ, Apers S, Pieters L. Phytochemical and biological investigations of Elaeodendron schlechteranum. J Ethnopharmacol. 2010 Jun 16;129(3):319-26. doi: 10.1016/j.jep.2010.03.034. Epub 2010 Apr 3. PubMed PMID: 20371284. |
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