購物車 
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Elaiophylin
- names：
Elaiophylin
- CAS號(hào)：
37318-06-2
MDL Number： - MF(分子式)： C54H88O18 MW(分子量)： 1025.28
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規(guī)格 | 純度 | 價(jià)格 (￥) | 現(xiàn)價(jià)(￥) | 特價(jià)(￥) | 庫存描述 | 數(shù)量 | 總計(jì) (￥) |
|---|
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| 中文別名 | (3E,5E,7S,8S,11E,13E,15S,16S)-8,16-bis((2S,3R,4S)-4-((2R,4R,5R,6R)-4-(((2R,4S,5S,6S)-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5-ethyl-2-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-3-hydroxypentan-2-yl)-7,15-dimethyl-1,9-dioxacyclohexadeca-3,5,11,13-tetraene-2,10-dione |
| 英文別名 | Elaiophylin |
| CAS號(hào) | 37318-06-2 |
| Inchi | InChI=1S/C54H88O18/c1-13-37-33(9)71-53(63,25-41(37)67-45-23-39(55)49(61)35(11)65-45)31(7)47(59)29(5)51-27(3)19-15-17-22-44(58)70-52(28(4)20-16-18-21-43(57)69-51)30(6)48(60)32(8)54(64)26-42(38(14-2)34(10)72-54)68-46-24-40(56)50(62)36(12)66-46/h15-22,27-42,45-52,55-56,59-64H,13-14,23-26H2,1-12H3/b19-15+,20-16+,21-18+,22-17+/t27-,28-,29-,30-,31-,32-,33+,34+,35-,36-,37+,38+,39-,40-,41+,42+,45-,46-,47+,48+,49+,50+,51-,52-,53+,54+/m0/s1 |
| InchiKey | OSERMIPXNLXAPD-MJMYBOKFSA-N |
| 分子式 Formula | C54H88O18 |
| 分子量 Molecular Weight | 1025.28 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲(chǔ)藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產(chǎn)品說明 | Elaiophylin(CAS:37318-06-2):僅限應(yīng)用于工業(yè)或者科學(xué)研究過程中非醫(yī)療目的，不應(yīng)用于人類或動(dòng)物的臨床診斷以及治過程療，該產(chǎn)品非藥用，非食用。 |
| Introduction | Elaiophylin is a macrolide antibiotic first isolated from Streptomyces melanosporus. Elaiophylin demonstrates antifungal activity as well as cytotoxicity against mammalian tumor cells, protozoa, and nematodes. This compound has displayed immunosuppressive activity through inhibition of B-cell stimulation and inhibiting proliferation of lymphocytes stimulated by mitogens. Elaiophylin is an inhibitor of 5 α-Reductase and NOS. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Lim HN, Jang JP, Han JM, Jang JH, Ahn JS, Jung HJ. Antiangiogenic Potential of Microbial Metabolite Elaiophylin for Targeting Tumor Angiogenesis. Molecules. 2018 Mar 2;23(3). pii: E563. doi: 10.3390/molecules23030563. PubMed PMID: 29498688; PubMed Central PMCID: PMC6017006. |
| [2]Wang G, Zhou P, Chen X, Zhao L, Tan J, Yang Y, Fang Y, Zhou J. The novel autophagy inhibitor elaiophylin exerts antitumor activity against multiple myeloma with mutant TP53 in part through endoplasmic reticulum stress-induced apoptosis. Cancer Biol Ther. 2017 Aug 3;18(8):584-595. doi: 10.1080/15384047.2017.1345386. Epub 2017 Jul 18. PubMed PMID: 28718729; PubMed Central PMCID: PMC5653199. |
| [3] Jiang M, Yin M, Wu S, Han X, Ji K, Wen M, Lu T. GdmRIII, a TetR Family Transcriptional Regulator, Controls Geldanamycin and Elaiophylin Biosynthesis in Streptomyces autolyticus CGMCC0516. Sci Rep. 2017 Jul 6;7(1):4803. doi: 10.1038/s41598-017-05073-x. PubMed PMID: 28684749; PubMed Central PMCID: PMC5500506. |
| [4] Han Y, Tian E, Xu D, Ma M, Deng Z, Hong K. Halichoblelide D, a New Elaiophylin Derivative with Potent Cytotoxic Activity from Mangrove-Derived Streptomyces sp. 219807. Molecules. 2016 Jul 25;21(8). pii: E970. doi: 10.3390/molecules21080970. PubMed PMID: 27463707; PubMed Central PMCID: PMC6273579. |
| [5] Sheng Y, Lam PW, Shahab S, Santosa DA, Proteau PJ, Zabriskie TM, Mahmud T. Identification of Elaiophylin Skeletal Variants from the Indonesian Streptomyces sp. ICBB 9297. J Nat Prod. 2015 Nov 25;78(11):2768-75. doi: 10.1021/acs.jnatprod.5b00752. Epub 2015 Oct 28. PubMed PMID: 26510047. |
6: Zhao X, Fang Y, Yang Y, Qin Y, Wu P, Wang T, Lai H, Meng L, Wang D, Zheng Z, Lu X, Zhang H, Gao Q, Zhou J, Ma D. Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells. Autophagy. 2015;11(10):1849-63. doi: 10.1080/15548627.2015.1017185. PubMed PMID: 25893854; PubMed Central PMCID: PMC4824600.
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