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Protein kinase inhibitor peptide

NMR下載 COA and HPLC MSDS下載
names：
L-Isoleucine, L-threonyl-L-threonyl-L-tyrosyl-L-alanyl-L-alpha-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylglycyl-L-arginyl-L-threonylglycyl-L-arginyl-L-arginyl-L-asparaginyl-L-alanyl-
CAS號：
128022-93-5
MDL Number：
MF(分子式)： C84H136N28O27 MW(分子量)： 1970.18
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	L-Isoleucine, L-threonyl-L-threonyl-L-tyrosyl-L-alanyl-L-alpha-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylglycyl-L-arginyl-L-threonylglycyl-L-arginyl-L-arginyl-L-asparaginyl-L-alanyl-
英文別名	Protein kinase inhibitor peptide; PKIP;
CAS號	128022-93-5
Inchi
InchiKey	ZLKNTGQAQQSIFV-HQAKDUOCSA-N
分子式 Formula	C84H136N28O27
分子量 Molecular Weight	1970.18
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	Protein kinase inhibitor peptide(CAS:128022-93-5):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	Protein kinase inhibitor peptide corresponds to the inhibitory domain of the heat-stable protein kinase inhibitor.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
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[1]Dalton GD, Dewey WL. Protein kinase inhibitor peptide (PKI): a family of endogenous neuropeptides that modulate neuronal cAMP-dependent protein kinase function. Neuropeptides. 2006 Feb;40(1):23-34. Epub 2006 Jan 26. Review. PubMed PMID: 16442618.

[2]Olah GA, Mitchell RD, Sosnick TR, Walsh DA, Trewhella J. Solution structure of the cAMP-dependent protein kinase catalytic subunit and its contraction upon binding the protein kinase inhibitor peptide. Biochemistry. 1993 Apr 13;32(14):3649-57. PubMed PMID: 8385485.

[3] Taffs RE, Sitkovsky MV. Modulation of the effector functions of cytolytic T-lymphocytes with synthetic peptide inhibitors of protein kinases. J Pharm Sci. 1992 Jan;81(1):37-44. PubMed PMID: 1619567.

[4] Glass DB, Feller MJ, Levin LR, Walsh DA. Structural basis for the low affinities of yeast cAMP-dependent and mammalian cGMP-dependent protein kinases for protein kinase inhibitor peptides. Biochemistry. 1992 Feb 18;31(6):1728-34. PubMed PMID: 1310617.

[5] Godwin AJ, Green LM, Walsh MP, McDonald JR, Walsh DA, Fletcher WH. In situ regulation of cell-cell communication by the cAMP-dependent protein kinase and protein kinase C. Mol Cell Biochem. 1993 Nov;127-128:293-307. PubMed PMID: 7935358.

6: Olsen SR, Uhler MD. Affinity purification of the C alpha and C beta isoforms of the catalytic subunit of cAMP-dependent protein kinase. J Biol Chem. 1989 Nov 5;264(31):18662-6. PubMed PMID: 2553718.7: Kurokawa H, Kato K, Iwanaga T, Sugi T, Sudo A, Kobayashi K, Gong H, Takemae H, Recuenco FC, Horimoto T, Akashi H. Identification of Toxoplasma gondii cAMP dependent protein kinase and its role in the tachyzoite growth. PLoS One. 2011;6(7):e22492. doi: 10.1371/journal.pone.0022492. Epub 2011 Jul 20. PubMed PMID: 21799871; PubMed Central PMCID: PMC3140512.8: Ruth P, Kamm S, Nau U, Pfeifer A, Hofmann F. A cGMP kinase mutant with increased sensitivity to the protein kinase inhibitor peptide PKI(5-24). Biol Chem. 1996 Jul-Aug;377(7-8):513-20. PubMed PMID: 8922286.9: Fernandez A, Mery J, Vandromme M, Basset M, Cavadore JC, Lamb NJ. Effective intracellular inhibition of the cAMP-dependent protein kinase by microinjection of a modified form of the specific inhibitor peptide PKi in living fibroblasts. Exp Cell Res. 1991 Aug;195(2):468-77. PubMed PMID: 2070829.10: Zimmermann LJ, Lee WS, Smith BT, Post M. Cyclic AMP-dependent protein kinase does not regulate CTP:phosphocholine cytidylyltransferase activity in maturing type II cells. Biochim Biophys Acta. 1994 Feb 10;1211(1):44-50. PubMed PMID: 8123681.1

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