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7-甲氧基香豆素-3-羧酸【CAS 20300-59-8】
NMR COA MSDS - Names：
7-Methoxycoumarin-3-carboxylic Acid
- CAS號：
20300-59-8
MDL Number： MFCD00452770 - MF(分子式)： C11H8O5 MW(分子量)： 220.18
- EINECS: Reaxys Number:384199
- Pubchem ID:135727041 Brand:BIOFOUNT
7-甲氧基香豆素-3-羧酸 7-Methoxycoumarin-3-carboxylic acid (20300-59-8)在某些多色熒光應用（如核酸和蛋白質微陣列、原位雜交和免疫熒光）中與更長波長的探針一起使用時，可提供可區分的對比度。熒光：λex 330 nm; λem 402 nm in 0.1 M Tris pH 9.0。還用于開發用于分析蛋白酶活性的 FRET 探針。
| 貨品編碼 | 規格 | 純度 | 價格 (￥) | 現價(￥) | 特價(￥) | 庫存描述 | 數量 | 總計 (￥) |
|---|---|---|---|---|---|---|---|---|
| HCC327856-1g | 1g | 97% | ￥ 2150.00 | ￥ 2150.00 | Instock1days | ￥ 0.00 | ||
| HCC327856-500mg | 500mg | 97% | ￥ 1290.00 | ￥ 1290.00 | Instock1days | ￥ 0.00 | ||
| HCC327856-100mg | 100mg | 97% | ￥ 370.00 | ￥ 370.00 | Instock1days | ￥ 0.00 |
| 中文別名 | 7-甲氧基香豆素-3-羧酸;20300-59-8;Amine-reactive fluorescent probe;7-Methoxy-2-oxo-2H-1-benzopyran-3-carboxylic acid ;MC |
| 英文別名 | 7-Methoxycoumarin-3-carboxylic Acid |
| CAS號 | 20300-59-8 |
| Inchi | 1S/C11H8O5/c1-15-7-3-2-6-4-8(10(12)13)11(14)16-9(6)5-7/h2-5H,1H3,(H,12,13) |
| InchiKey | EEGNDSSWAOLFN-UHFFFAOYSA-N |
| 分子式 Formula | C11H8O5 |
| 分子量 Molecular Weight | 220.18 |
| 溶解度Solubility | Soluble in DMSO |
| 性狀 | solid |
| 儲藏條件 Storage conditions | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
| 產品說明 | 7-甲氧基香豆素-3-羧酸 7-Methoxycoumarin-3-carboxylic acid (20300-59-8)在某些多色熒光應用（如核酸和蛋白質微陣列、原位雜交和免疫熒光）中與更長波長的探針一起使用時，可提供可區分的對比度。 |
| Introduction | 7-Methoxycoumarin-3-carboxylic Acid(CAS:20300-59-8):only use for non-medical purposes in industrial or scientific research, and not for clinical diagnosis and treatment of humans or animals. This product is not medicinal or edible. |
| Application1 | |
| Application2 | |
| Application3 |
| 1.Evaluation of a 7-Methoxycoumarin-3-carboxylic Acid Ester Derivative as a Fluorescent, Cell-Cleavable, Phosphonate Protecting Group. |
| 2. An alternative quenched fluorescence substrate for Pz-peptidase Authors: Tisljar U, et al. Journal: Anal Biochem (1990): 112-5 |
| 3. Quantitation of platelet-activating factor by high-performance liquid chromatography with fluorescent detection Authors: Mita H, Yasueda H, Hayakawa T, Shida T. Journal: Anal Biochem (1989): 131 |
1.Evaluation of a 7-Methoxycoumarin-3-carboxylic Acid Ester Derivative as a Fluorescent, Cell-Cleavable, Phosphonate Protecting Group.
Wiemer AJ1, Shippy RR2, Kilcollins AM3, Li J1, Hsiao CH1, Barney RJ4, Geng ML5, Wiemer DF6. Chembiochem. 2016 Jan 1;17(1):52-5. doi: 10.1002/cbic.201500484. Epub 2015 Nov 19.
Cell-cleavable protecting groups often enhance cellular delivery of species that are charged at physiological pH. Although several phosphonate protecting groups have achieved clinical success, it remains difficult to use these prodrugs in live cells to clarify biological mechanisms. Here, we present a strategy that uses a 7-methoxycoumarin-3-carboxylic acid ester as a fluorescent protecting group. This strategy was applied to synthesis of an (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) analogue to assess cellular uptake and human Vγ9Vδ2 T?cell activation. The fluorescent ester displayed low cellular toxicity (IC50 >100 μm) and strong T cell activation (EC50 =0.018 μm) relative to the unprotected anion (EC50 =23 μm). The coumarin-derived analogue allowed no-wash analysis of biological deprotection, which revealed rapid internalization of the prodrug. These results demonstrate that fluorescent groups can be applied both as functional drug delivery tools and useful biological probes of drug uptake.
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